Diagnosis and management of dementia with lewy bodies : Third report of the DLB consortium
Identifieur interne : 002B33 ( Main/Exploration ); précédent : 002B32; suivant : 002B34Diagnosis and management of dementia with lewy bodies : Third report of the DLB consortium
Auteurs : I. G. Mckeith [Royaume-Uni] ; D. W. Dickson [États-Unis] ; J. Lowe [Royaume-Uni] ; M. Emre [Turquie] ; J. T. O'Brien [Royaume-Uni] ; H. Feldman [Canada] ; J. Cummings [États-Unis] ; J. E. Duda [États-Unis] ; C. Lippa [États-Unis] ; E. K. Perry [Royaume-Uni] ; D. Aarsland [Norvège] ; H. Arai [Japon] ; C. G. Ballard [Royaume-Uni] ; B. Boeve [États-Unis] ; D. J. Burn [Royaume-Uni] ; D. Costa [Portugal] ; T. Del Ser [Espagne] ; B. Duboi [France] ; D. Galasko [États-Unis] ; S. Gauthier [Canada] ; C. G. Goetz [États-Unis] ; E. Gomez-Tortos [Espagne] ; F. G. Halliday [Australie] ; L. A. Hansen [États-Unis] ; J. Hardy [États-Unis] ; T. Iwatsubo [Japon] ; R. N. Kalaria [Royaume-Uni] ; D. Kaufer [États-Unis] ; R. A. Kenny [Royaume-Uni] ; A. Korczyn [Israël] ; K. Kosaka ; V. M.-Y. Lee ; A. Lees ; I. Litvan ; E. Londos ; O. L. Lopez ; S. Minoshima ; Y. Mizuno ; J. A. Molina ; E. B. Mukaetova-Ladinska [Royaume-Uni] ; F. Pasquier ; R. H. Perry [Royaume-Uni] ; J. B. Schulz ; J. Q. Trojanowski ; M. YamadaSource :
- Neurology [ 0028-3878 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and Parkinson disease with dementia may be difficult to apply in clinical settings and in such cases the term most appropriate to each individual patient should be used. Generic terms such as Lewy body (LB) disease are often helpful. The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. The new criteria take into account both Lewy-related and Alzheimer disease (AD)-type pathology to allocate a probability that these are associated with the clinical DLB syndrome. Finally, the authors suggest patient management guidelines including the need for accurate diagnosis, a target symptom approach, and use of appropriate outcome measures. There is limited evidence about specific interventions but available data suggest only a partial response of motor symptoms to levodopa: severe sensitivity to typical and atypical antipsychotics in ∼50%, and improvements in attention, visual hallucinations, and sleep disorders with cholinesterase inhibitors.
Affiliations:
- Australie, Canada, Espagne, France, Israël, Japon, Norvège, Portugal, Royaume-Uni, Turquie, États-Unis
- Angleterre, Communauté de Madrid, Grand Londres, Nottinghamshire, Île-de-France
- Londres, Madrid, Nottingham, Paris, Sydney
- Université de Nottingham
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000868
- to stream PascalFrancis, to step Curation: 000455
- to stream PascalFrancis, to step Checkpoint: 000804
- to stream Main, to step Merge: 002E72
- to stream Main, to step Curation: 002B33
Le document en format XML
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Kaufer</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Dept. of Neurology CB 7025, University of North Carolina School of Medicine</s1><s2>Chapel Hill</s2><s3>USA</s3><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chapel Hill</wicri:noRegion></affiliation></author><author><name sortKey="Kenny, R A" sort="Kenny, R A" uniqKey="Kenny R" first="R. A." last="Kenny">R. A. Kenny</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Korczyn, A" sort="Korczyn, A" uniqKey="Korczyn A" first="A." last="Korczyn">A. 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Lopez</name></author><author><name sortKey="Minoshima, S" sort="Minoshima, S" uniqKey="Minoshima S" first="S." last="Minoshima">S. Minoshima</name></author><author><name sortKey="Mizuno, Y" sort="Mizuno, Y" uniqKey="Mizuno Y" first="Y." last="Mizuno">Y. Mizuno</name></author><author><name sortKey="Molina, J A" sort="Molina, J A" uniqKey="Molina J" first="J. A." last="Molina">J. A. Molina</name></author><author><name sortKey="Mukaetova Ladinska, E B" sort="Mukaetova Ladinska, E B" uniqKey="Mukaetova Ladinska E" first="E. B." last="Mukaetova-Ladinska">E. B. 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Perry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Schulz, J B" sort="Schulz, J B" uniqKey="Schulz J" first="J. B." last="Schulz">J. B. Schulz</name></author><author><name sortKey="Trojanowski, J Q" sort="Trojanowski, J Q" uniqKey="Trojanowski J" first="J. Q." last="Trojanowski">J. Q. Trojanowski</name></author><author><name sortKey="Yamada, M" sort="Yamada, M" uniqKey="Yamada M" first="M." last="Yamada">M. Yamada</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0077698</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0077698 INIST</idno><idno type="RBID">Pascal:06-0077698</idno><idno type="wicri:Area/PascalFrancis/Corpus">000868</idno><idno type="wicri:Area/PascalFrancis/Curation">000455</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000804</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000804</idno><idno type="wicri:doubleKey">0028-3878:2005:Mckeith I:diagnosis:and:management</idno><idno type="wicri:Area/Main/Merge">002E72</idno><idno type="wicri:Area/Main/Curation">002B33</idno><idno type="wicri:Area/Main/Exploration">002B33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Diagnosis and management of dementia with lewy bodies : Third report of the DLB consortium</title><author><name sortKey="Mckeith, I G" sort="Mckeith, I G" uniqKey="Mckeith I" first="I. G." last="Mckeith">I. G. Mckeith</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Dickson, D W" sort="Dickson, D W" uniqKey="Dickson D" first="D. W." last="Dickson">D. W. Dickson</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuropathology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Lowe, J" sort="Lowe, J" uniqKey="Lowe J" first="J." last="Lowe">J. Lowe</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Pathology, School of Molecular Medical Sciences, University of Nottingham</s1><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName><orgName type="university">Université de Nottingham</orgName></affiliation></author><author><name sortKey="Emre, M" sort="Emre, M" uniqKey="Emre M" first="M." last="Emre">M. Emre</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Istanbul University, Istanbul Faculty of Medicine</s1><s3>TUR</s3><sZ>4 aut.</sZ></inist:fA14><country>Turquie</country><wicri:noRegion>Department of Neurology, Istanbul University, Istanbul Faculty of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, J T" sort="O Brien, J T" uniqKey="O Brien J" first="J. T." last="O'Brien">J. T. O'Brien</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Feldman, H" sort="Feldman, H" uniqKey="Feldman H" first="H." last="Feldman">H. Feldman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>UBC Division of Neurology, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Cummings, J" sort="Cummings, J" uniqKey="Cummings J" first="J." last="Cummings">J. Cummings</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, UCLA Medical School Alzheimer's Disease Center</s1><s2>Los Angeles, CA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation></author><author><name sortKey="Duda, J E" sort="Duda, J E" uniqKey="Duda J" first="J. E." last="Duda">J. E. Duda</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Parkinson's Disease Research, Education and Clinical Center, Philadelphia VAMC</s1><s2>PA</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Lippa, C" sort="Lippa, C" uniqKey="Lippa C" first="C." last="Lippa">C. Lippa</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Memory Disorders Program, Drexel University School of Medicine</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA</wicri:noRegion></affiliation></author><author><name sortKey="Perry, E K" sort="Perry, E K" uniqKey="Perry E" first="E. K." last="Perry">E. K. Perry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D." last="Aarsland">D. Aarsland</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Section of Geriatric Psychiatry, Stavanger University Hospital</s1><s3>NOR</s3><sZ>11 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Section of Geriatric Psychiatry, Stavanger University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Arai, H" sort="Arai, H" uniqKey="Arai H" first="H." last="Arai">H. Arai</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Geriatric & Respiratory Medicine, Tohoku University School of Medicine</s1><s2>Miyagi</s2><s3>JPN</s3><sZ>12 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Miyagi</wicri:noRegion></affiliation></author><author><name sortKey="Ballard, C G" sort="Ballard, C G" uniqKey="Ballard C" first="C. G." last="Ballard">C. G. Ballard</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Wolfson Centre for Age-Related Diseases</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Boeve, B" sort="Boeve, B" uniqKey="Boeve B" first="B." last="Boeve">B. Boeve</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rochester, MN</wicri:noRegion></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Costa, D" sort="Costa, D" uniqKey="Costa D" first="D." last="Costa">D. Costa</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Institute of Nuclear Medicine, HPP Medicina Molecular, SA</s1><s2>Porto</s2><s3>PRT</s3><sZ>16 aut.</sZ></inist:fA14><country>Portugal</country><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Del Ser, T" sort="Del Ser, T" uniqKey="Del Ser T" first="T." last="Del Ser">T. Del Ser</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Section of Neurology, Hospital Severo Ochoa</s1><s2>Madrid</s2><s3>ESP</s3><sZ>17 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Duboi, B" sort="Duboi, B" uniqKey="Duboi B" first="B." last="Duboi">B. Duboi</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Hopital La Salpêtnère</s1><s2>Paris</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Galasko, D" sort="Galasko, D" uniqKey="Galasko D" first="D." last="Galasko">D. Galasko</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Dept. of Neuroscience, University of California San Diego</s1><s2>La Jolla</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla</wicri:noRegion></affiliation></author><author><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S." last="Gauthier">S. Gauthier</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>MCSA Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging</s1><s2>Quebec</s2><s3>CAN</s3><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C. G." last="Goetz">C. G. Goetz</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Neurological Sciences, Rush University Medical Center</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chicago, IL</wicri:noRegion></affiliation></author><author><name sortKey="Gomez Tortos, E" sort="Gomez Tortos, E" uniqKey="Gomez Tortos E" first="E." last="Gomez-Tortos">E. Gomez-Tortos</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Fundación Jiménez Diaz, Servicio de Neurología</s1><s2>Madrid</s2><s3>ESP</s3><sZ>22 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Halliday, F G" sort="Halliday, F G" uniqKey="Halliday F" first="F. G." last="Halliday">F. G. Halliday</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Prince of Wales Medical Research Institute</s1><s2>Sydney</s2><s3>AUS</s3><sZ>23 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Hansen, L A" sort="Hansen, L A" uniqKey="Hansen L" first="L. A." last="Hansen">L. A. Hansen</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Dept. of Pathology, University of California San Diego</s1><s2>La Jolla</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla</wicri:noRegion></affiliation></author><author><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Laboratory of Neurogenetics, National Institute on Aging</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Iwatsubo, T" sort="Iwatsubo, T" uniqKey="Iwatsubo T" first="T." last="Iwatsubo">T. Iwatsubo</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Neuropathology & Neuroscience, University of Tokyo</s1><s3>JPN</s3><sZ>26 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Department of Neuropathology & Neuroscience, University of Tokyo</wicri:noRegion></affiliation></author><author><name sortKey="Kalaria, R N" sort="Kalaria, R N" uniqKey="Kalaria R" first="R. N." last="Kalaria">R. N. Kalaria</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kaufer, D" sort="Kaufer, D" uniqKey="Kaufer D" first="D." last="Kaufer">D. Kaufer</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Dept. of Neurology CB 7025, University of North Carolina School of Medicine</s1><s2>Chapel Hill</s2><s3>USA</s3><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chapel Hill</wicri:noRegion></affiliation></author><author><name sortKey="Kenny, R A" sort="Kenny, R A" uniqKey="Kenny R" first="R. A." last="Kenny">R. A. Kenny</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Korczyn, A" sort="Korczyn, A" uniqKey="Korczyn A" first="A." last="Korczyn">A. Korczyn</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Department of Neurology, Tel-Aviv University</s1><s3>ISR</s3><sZ>30 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Department of Neurology, Tel-Aviv University</wicri:noRegion></affiliation></author><author><name sortKey="Kosaka, K" sort="Kosaka, K" uniqKey="Kosaka K" first="K." last="Kosaka">K. Kosaka</name></author><author><name sortKey="Lee, V M Y" sort="Lee, V M Y" uniqKey="Lee V" first="V. M.-Y." last="Lee">V. M.-Y. Lee</name></author><author><name sortKey="Lees, A" sort="Lees, A" uniqKey="Lees A" first="A." last="Lees">A. Lees</name></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name></author><author><name sortKey="Londos, E" sort="Londos, E" uniqKey="Londos E" first="E." last="Londos">E. Londos</name></author><author><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O. L." last="Lopez">O. L. Lopez</name></author><author><name sortKey="Minoshima, S" sort="Minoshima, S" uniqKey="Minoshima S" first="S." last="Minoshima">S. Minoshima</name></author><author><name sortKey="Mizuno, Y" sort="Mizuno, Y" uniqKey="Mizuno Y" first="Y." last="Mizuno">Y. Mizuno</name></author><author><name sortKey="Molina, J A" sort="Molina, J A" uniqKey="Molina J" first="J. A." last="Molina">J. A. Molina</name></author><author><name sortKey="Mukaetova Ladinska, E B" sort="Mukaetova Ladinska, E B" uniqKey="Mukaetova Ladinska E" first="E. B." last="Mukaetova-Ladinska">E. B. Mukaetova-Ladinska</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, F" sort="Pasquier, F" uniqKey="Pasquier F" first="F." last="Pasquier">F. Pasquier</name></author><author><name sortKey="Perry, R H" sort="Perry, R H" uniqKey="Perry R" first="R. H." last="Perry">R. H. Perry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Ageing and Health, University of Newcastle upon Tyne</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>27 aut.</sZ><sZ>29 aut.</sZ><sZ>40 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Institute for Ageing and Health, University of Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Schulz, J B" sort="Schulz, J B" uniqKey="Schulz J" first="J. B." last="Schulz">J. B. Schulz</name></author><author><name sortKey="Trojanowski, J Q" sort="Trojanowski, J Q" uniqKey="Trojanowski J" first="J. Q." last="Trojanowski">J. Q. Trojanowski</name></author><author><name sortKey="Yamada, M" sort="Yamada, M" uniqKey="Yamada M" first="M." last="Yamada">M. Yamada</name></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical management</term><term>Diagnosis</term><term>Lewy body dementia</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Diagnostic</term><term>Conduite à tenir</term><term>Démence corps Lewy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and Parkinson disease with dementia may be difficult to apply in clinical settings and in such cases the term most appropriate to each individual patient should be used. Generic terms such as Lewy body (LB) disease are often helpful. The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. The new criteria take into account both Lewy-related and Alzheimer disease (AD)-type pathology to allocate a probability that these are associated with the clinical DLB syndrome. Finally, the authors suggest patient management guidelines including the need for accurate diagnosis, a target symptom approach, and use of appropriate outcome measures. There is limited evidence about specific interventions but available data suggest only a partial response of motor symptoms to levodopa: severe sensitivity to typical and atypical antipsychotics in ∼50%, and improvements in attention, visual hallucinations, and sleep disorders with cholinesterase inhibitors.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Israël</li><li>Japon</li><li>Norvège</li><li>Portugal</li><li>Royaume-Uni</li><li>Turquie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Nottinghamshire</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Madrid</li><li>Nottingham</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><noCountry><name sortKey="Kosaka, K" sort="Kosaka, K" uniqKey="Kosaka K" first="K." last="Kosaka">K. Kosaka</name><name sortKey="Lee, V M Y" sort="Lee, V M Y" uniqKey="Lee V" first="V. M.-Y." last="Lee">V. M.-Y. Lee</name><name sortKey="Lees, A" sort="Lees, A" uniqKey="Lees A" first="A." last="Lees">A. Lees</name><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><name sortKey="Londos, E" sort="Londos, E" uniqKey="Londos E" first="E." last="Londos">E. Londos</name><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O. L." last="Lopez">O. L. Lopez</name><name sortKey="Minoshima, S" sort="Minoshima, S" uniqKey="Minoshima S" first="S." last="Minoshima">S. Minoshima</name><name sortKey="Mizuno, Y" sort="Mizuno, Y" uniqKey="Mizuno Y" first="Y." last="Mizuno">Y. Mizuno</name><name sortKey="Molina, J A" sort="Molina, J A" uniqKey="Molina J" first="J. A." last="Molina">J. A. Molina</name><name sortKey="Pasquier, F" sort="Pasquier, F" uniqKey="Pasquier F" first="F." last="Pasquier">F. Pasquier</name><name sortKey="Schulz, J B" sort="Schulz, J B" uniqKey="Schulz J" first="J. B." last="Schulz">J. B. Schulz</name><name sortKey="Trojanowski, J Q" sort="Trojanowski, J Q" uniqKey="Trojanowski J" first="J. Q." last="Trojanowski">J. Q. Trojanowski</name><name sortKey="Yamada, M" sort="Yamada, M" uniqKey="Yamada M" first="M." last="Yamada">M. Yamada</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Mckeith, I G" sort="Mckeith, I G" uniqKey="Mckeith I" first="I. G." last="Mckeith">I. G. Mckeith</name></noRegion><name sortKey="Ballard, C G" sort="Ballard, C G" uniqKey="Ballard C" first="C. G." last="Ballard">C. G. Ballard</name><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><name sortKey="Kalaria, R N" sort="Kalaria, R N" uniqKey="Kalaria R" first="R. N." last="Kalaria">R. N. Kalaria</name><name sortKey="Kenny, R A" sort="Kenny, R A" uniqKey="Kenny R" first="R. A." last="Kenny">R. A. Kenny</name><name sortKey="Lowe, J" sort="Lowe, J" uniqKey="Lowe J" first="J." last="Lowe">J. Lowe</name><name sortKey="Mukaetova Ladinska, E B" sort="Mukaetova Ladinska, E B" uniqKey="Mukaetova Ladinska E" first="E. B." last="Mukaetova-Ladinska">E. B. Mukaetova-Ladinska</name><name sortKey="O Brien, J T" sort="O Brien, J T" uniqKey="O Brien J" first="J. T." last="O'Brien">J. T. O'Brien</name><name sortKey="Perry, E K" sort="Perry, E K" uniqKey="Perry E" first="E. K." last="Perry">E. K. Perry</name><name sortKey="Perry, R H" sort="Perry, R H" uniqKey="Perry R" first="R. H." last="Perry">R. H. Perry</name></country><country name="États-Unis"><noRegion><name sortKey="Dickson, D W" sort="Dickson, D W" uniqKey="Dickson D" first="D. W." last="Dickson">D. W. Dickson</name></noRegion><name sortKey="Boeve, B" sort="Boeve, B" uniqKey="Boeve B" first="B." last="Boeve">B. Boeve</name><name sortKey="Cummings, J" sort="Cummings, J" uniqKey="Cummings J" first="J." last="Cummings">J. Cummings</name><name sortKey="Duda, J E" sort="Duda, J E" uniqKey="Duda J" first="J. E." last="Duda">J. E. Duda</name><name sortKey="Galasko, D" sort="Galasko, D" uniqKey="Galasko D" first="D." last="Galasko">D. Galasko</name><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C. G." last="Goetz">C. G. Goetz</name><name sortKey="Hansen, L A" sort="Hansen, L A" uniqKey="Hansen L" first="L. A." last="Hansen">L. A. Hansen</name><name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name><name sortKey="Kaufer, D" sort="Kaufer, D" uniqKey="Kaufer D" first="D." last="Kaufer">D. Kaufer</name><name sortKey="Lippa, C" sort="Lippa, C" uniqKey="Lippa C" first="C." last="Lippa">C. Lippa</name></country><country name="Turquie"><noRegion><name sortKey="Emre, M" sort="Emre, M" uniqKey="Emre M" first="M." last="Emre">M. Emre</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Feldman, H" sort="Feldman, H" uniqKey="Feldman H" first="H." last="Feldman">H. Feldman</name></noRegion><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S." last="Gauthier">S. Gauthier</name></country><country name="Norvège"><noRegion><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D." last="Aarsland">D. Aarsland</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Arai, H" sort="Arai, H" uniqKey="Arai H" first="H." last="Arai">H. Arai</name></noRegion><name sortKey="Iwatsubo, T" sort="Iwatsubo, T" uniqKey="Iwatsubo T" first="T." last="Iwatsubo">T. Iwatsubo</name></country><country name="Portugal"><noRegion><name sortKey="Costa, D" sort="Costa, D" uniqKey="Costa D" first="D." last="Costa">D. Costa</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Del Ser, T" sort="Del Ser, T" uniqKey="Del Ser T" first="T." last="Del Ser">T. Del Ser</name></region><name sortKey="Gomez Tortos, E" sort="Gomez Tortos, E" uniqKey="Gomez Tortos E" first="E." last="Gomez-Tortos">E. Gomez-Tortos</name></country><country name="France"><region name="Île-de-France"><name sortKey="Duboi, B" sort="Duboi, B" uniqKey="Duboi B" first="B." last="Duboi">B. Duboi</name></region></country><country name="Australie"><noRegion><name sortKey="Halliday, F G" sort="Halliday, F G" uniqKey="Halliday F" first="F. G." last="Halliday">F. G. Halliday</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Korczyn, A" sort="Korczyn, A" uniqKey="Korczyn A" first="A." last="Korczyn">A. Korczyn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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